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Dear friend,
Have you ever wondered why as you were
aging you were loosing your ability to recover from injury,
to gain lean body mass, and to sustain the same intensity in
your work-outs. Why your skin wrinkled and lost its
elasticity, and why you were more attracted by a relax
evening than a party one.
Did you also ever
wondered why women were not able to pack on muscle and
perform to the same levels as men? And likewise you were not
able to pack on muscle like most competitive bodybuilders?
An important part of
the answer lies in testosterone.
This hormone, which level is
usually
100 times lower in women than man, decreases with age,
and is often consumed in a derivative form by many
bodybuilders, is in great part responsible for a muscle
building and and health in general.
Now, unless you are pleased to undergo
aging, not being able to achieve the athletic performance,
you will want to read further to learn more about
testosterone and how you can boost your own natural
testosterone levels. Increase your low testosterone
with a testosterone enhancer bodybuilding supplement.
...to boost your own natural testosterone within only a few
days and become the king of the weight, board and bed rooms!
What is testosterone
 (Δ4-androstene-17β-ol,3-one
– C19H28O2) is considered
to be the primary sexual male hormone.
Effect of
testosterone
[Netrients’
bodybuilding supplement
Testone®
anti estrogen and natural testosterone booster
dramatically increases plasmatic free testosterone level,
hence noticeably increasing these effects]
The protein synthesis
(anabolism) from the target tissues (translates to increased
actins and myosin contractile proteins in the case of muscle
fibers, resulting in increased strength and muscle volume;
1g protein = 5g muscle) is the principal mission of
testosterone.
Testosterone is
converted into DHT (5-α-hidrotestosterone) responsible for
male androgenic characteristics (growth of sexual tissues),
for the process of spermatogenesis as well as for the mating
behavior [combining Netrients's PUMP and
Testone®
anti estrogen and natural testosterone booster
is the best of all natural sexual performance
enhancers].
At the muscle level,
testosterone diffuses through the cell membrane to form a
cytoplasmic complex with a specific receptor. This complex
is transferred into the cell’s nucleus where it induces the
sysnthesis or RNA (ribonucleic acid), then the protein
synthesis. This process is referred to as anabolism
(nitrogen retention, increase in mass of muscle). Increase
your low testosterone
with a testosterone optimizer .
 Other
effects of testosterone are:
-
Improved sexual
health through increased libido (low testosterone level
are more then often the cause for low libido)
-
Increased lipid
metabolism (resulting in lipid utilization and fat loss)
[combination with Netrients Hi-GH hGH booster
and Ultra-Lean
fat burners will allows for an even greater fat
loss]
-
Increased creatine
phosphatase (resulting in increased strength, endurance
and muscle volume due to its osmotic power), muscle
glycogen (energy substrate) and associated muscle volume
(1g of glycogen calls for 2.7g of water) [combination
with Netrients PUMP allows for an even greater muscle
volumization]
-
Increase in
vascularity
-
Heart muscle
development and support (resulting in improved
cardio-vascular health [Netrients
bodybuilding supplement
Testone®
anti estrogen and
natural testosterone booster further supports
this through its CoQ10 optimal delivery]
-
Increased aerobic
capacity [combination with Netrients Oxygen allows for
an even greater aerobic capacity]
-
Increased production
of red blood cells and hemoglobin (resulting in improved
aerobic power and capacity) [combination with Netrients
Oxygen allows for an even greater aerobic capacity]
-
Increase in nerve
size (resulting in increased attention and flux speed)
pigmentation and bone support.
Natural testosterone
production
Natural testosterone is
also referred to as endogenous testosterone and is produced
by the body from cholesterol. The Leydig interstitial testis
cells produce Ninety percent of testosterone (through
stimulation by Luteinizing Hormone) [Netrients PUMP further
simulates the production of testosterone through its
stimulating effect on LH] while remaining ten percent is
produced the surenal glands, near the kidneys.
Testosterone
production regulation
As with other anterior
lobe pituitary hormones, gonadotrophins (interstitial cell
stimulating hormone such as LH) secretion is controlled by
releasing factors produced by hypothalamus. Testosterone
inhibit the pituitary gland through a feedback control
mechanism effective on the secretion of gonadotropins. The
secretion of testosterone is submitted to a periodicity with
a peak at the end of the night, when the prolactin is at its
minimum. Aging and stress are two factors reducing natural
testosterone production.
Available
testosterone
Only the free fraction
of the testosterone (2%) circulating in plasma is active.
The fraction of testosterone bounded to SBP (sex binding
protein, or TEBG for testosterone-estradiol binding protein)
constitutes an inactive pool [Netrients’
bodybuilding supplement
Testone®
anti estrogen and natural testosterone booster increases
plasmatic free testosterone level].
Increased plasmatic free
testosterone level causes an increase in the striated muscle
testosterone receptors.
The mean free
testosterone level in normal men is given as 0.56 µg / 100
ml of serum, and in normal women, 0.12 µg / 100 ml of serum.
The three main factors
influencing the level of plasmatic free testosterone are:
-
Change in secretion
– Age, stress (through increased secretion of prolactin,
a hormone with retro-inhibition effect on gonads) and
pathological disorders are the three main reasons for
decreased testosterone production. After 21, men
testosterone production gradually and continuously
decreases [Netrients’
bodybuilding supplement
Testone®
anti estrogen and natural testosterone booster increases
testosterone secretion the proven effect of its Zinc and
Magnesium balanced chelate formula].
-
Liberation of
already produced testosterone - Intense and brief
exercise creates an increase of blood testosterone by
liberation of already produced testosterone stocked in
testicular vascular system
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testosterone.jpg)
Testosterone
transformations
[Netrients’
bodybuilding supplement
Testone®
anti estrogen and natural testosterone booster favors an
increased plasmatic free testosterone level by preventing it
from being transformed into estrogen]
The most significant
route of metabolism is the conversion in vivo of
androstenedione to estradiol, estrone and estriol (estrogens
– main female sex hormone) via the oxidative removal of the
angular methyl group at carbon-19 by the aromatase enzyme.
This process, which synthesizes an aromatic ring via three
successive oxygenation, is referred to as aromatization and
is irreversible. The aromatase is a microsome P450
cytochrome oxygenase. Cytochromes are electron transporter
hemnenic proteins enclosing iron bounded to a poryphryine.
They are constituent of the respiratory chain. The P450 are
all trans membranous distinguishes themselves from the
electron transporters by their enzymatic activity, which is
the one of a mono-oxygenase. Oxygenases are enzymes using
NADH or NADPH as an electron donor to incorporate one or two
oxygen atoms from molecular oxygen into their substrate.
Aromatization has a
double negative effect in men, especially athletes in that
it, at once, lowers testosterone level (effects include
reduced libido, reduced fat utilization [combination with
Netrients Hi-GH
hGH booster and Netrients Ultra-Lean fat
burners
will allows for an even greater fat loss], and reduced
muscle protein synthesis), and increases estradiol (which
decreases secretion of hGH, a powerful anabolic peptide
hormone, decreases secretion of somatomedins which are
essential to the growth effect of testosterone, and can be
the source of water retention, acne and lower basal
metabolism) [Netrients’
Testone®
anti estrogen and natural testosterone booster prevents
testosterone from being transformed into estrogen].
Furthermore, it has been found that oestrogen has a
stimulating effect on the activity of aromatase, creating a
short loop vicious circle (the more testosterone is
converted into oestrogen, the more the aromatase enzyme is
active to convert more testosterone into oestrogen).
Finally, by decreasing fat utilization, oestrogen can make
it difficult for an individual to loose fat, and oestrogen
production has been shown to be increased with increased
body fat, creating an additional long loop vicious circle
[combination with Netrients Hi-GH hGH booster and
Lean fat burners will allows maximum fat loss]. Best
testosterone enhancer to boost your low
testosterone.
 Benefits
of Testone®
anti estrogen and natural testosterone booster
Testone®
anti estrogen and natural testosterone booster
greatly benefits all men over 21 by significantly improving
their vitality and overall health potentially leading to
greater longevity. More specifically,
Testone®
anti estrogen and natural testosterone booster’s
incredible testosterone boosting effect will lead to
increased libido and muscle mass (when combined with
exercise) along with associated strength.
Testone®
anti estrogen and natural testosterone booster will also
support heart health by significantly increasing its
strength, resulting in cardio-vascular power and capacity.
Furthermore Testone®
anti estrogen and natural testosterone booster testosterone
boosting effect will favor fat loss through increased basal
metabolism [combination with Netrients Hi-GH hGH booster
and Ultra-Lean fat burners will allows for an even
greater fat loss].
Interestingly,
Testone®
anti estrogen and natural testosterone booster has
three superposed effects:
-
Cyclic effect: By
preventing testosterone to be converted into estrogen,
it prevents the high estradiol to exert its stimulating
effect on aromataze
-
It increases the
free testosterone (usable) to total testosterone ratio
by reducing the sex hormone binding protein (SHBP), a
plasmatic protein which ties to free testosterone
-
The increased
plasmatic free testosterone level caused by the
accumulation effect leads to an increase in the number
of testosterone receptors in striated muscle
By minimizing the
production of any and all estrogens in the body through its
potent aromatase inhibition effect,
Testone®
anti estrogen and natural testosterone booster also
causes a positive effect on the
Hypothalamic-Pituitary-Testicular Axis (HPTA), causing your
body to greatly increase it's own natural testosterone
production. This is the safest way to naturally cause a
positive anabolic effect in order to gain muscle size,
strength, and endurance while promoting fat loss. Most
effective testosterone enhancer to boost your low
testosterone.
These effects
unquestionably make Testone®
anti estrogen and natural testosterone booster the
overall best anti aging, mans sexual heath, fat loss, anti
stretch marks, muscle fitness and body building supplement
available.
Testone®
anti estrogen and natural testosterone booster meets
Netrients motto “Live Long, Live Strong” and, why not, live
happier. Never have low testosterone again.
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Testone®
anti estrogen and natural testosterone booster
compared with other natural testosterone boosters
From the days where man
where told to ingest animal testicles extract to enhance
their own testosterone level, the food supplement and
nutraceutical industries have continuously attempted to
produce effective natural testosterone boosters.
Glandular extract only
contained small amounts of testosterone and natural
testosterone taken orally cannot be absorbed because it is
completely broken down by the liver. Ingestion of glandular
extract can only minimally elevate associated secretion
through a immune response of the homologue gland – clinical
trials have shown this approach not to significantly
increase testosterone level. The benefit of this approach
could only have been psychological (placebo effect).
Plant sterol and insects
analogs were the next evolution of natural testosterone
boosters, as it was supposed that they could, due to their
similar to androgen structure, stimulate to production of
testosterone. Again, science has demonstrated the
ineffectiveness of these compounds in elevating testosterone
level. In fact, some of those compounds are believed to
increase estrogen level and indirectly activate cebace
glands resulting in acne.
Saponins, such as
prontoncidin, found in high quality tribulus terestris
extracts have been shown in clinical studies to elevate male
subjects testosterone level by as much as 30%.
Unfortunately, this level of elevation is too low to
observe, in most subjects, effects (increased libido and
muscle mass, etc.). Furthermore, the increase of
testosterone level without the inactivation of aromatase
enzyme leads in increased testosterone conversion to
estrogen, which triggers the vicious circle effect
(increased activity) of aromatase. Thus, not only the
elevation is not important, but also it is temporary. Best
testosterone enhancer to boost your low testosterone.
Zinc-Magnesium Acetate
have been proven to, alone, elevate male subjects
testosterone level by as much as 30%. Again, the increase of
testosterone level without the inactivation of aromatase
enzyme leads in increased testosterone conversion to
estrogen, which triggers the vicious circle effect
(increased activity) of aromatase. Thus, not only the
elevation is not important, but it is also temporary.
A few other companies
have attempted to produce an effective natural natural
testosterone booster by preventing its conversion into
estrogens. However, the below comparison between the
innovative and exclusive delivery system of
Testone®
anti estrogen and natural testosterone booster
with these supplements explains why
Testone®
anti estrogen and natural testosterone booster
is so much more effective.
Testone®
anti estrogen and natural testosterone booster compared with
other anti estrogen
Among those are
formulations for oral administration of one of the same of
compounds used in Testone. When you orally ingest these compounds or any
testosterone related compound, the majority of these
compounds are broken down by the liver and become
essentially worthless or worse. In fact, clinical studies[1]
have demonstrated that when ingested, only 42% of this
specific ingredient is absorbed through the gastrointestinal
tract out of which fraction only 30% is not broken down by
liver, allowing only 12% of the ingested dose to penetrate
the general blood circulation. The worst part of it is that
the 29% fraction of the original ingested compound that is
broken-down by the liver becomes a suicidal inhibitor that
has 280 times the affinity of the natural testosterone. In
other words, it binds to the androgenic receptors of the
cell, preventing testosterone to bind to them and penetrate
the cells to exert their protein synthesis stimulation
action. The irreversibility of this binding results in a
snowball negative effect that can initially be observed by
decreased treatment efficiency and later by degradation of
the subject’s general condition (muscle mass loss, lowered
energy, increase low testosterone, etc.). Incredible
testosterone enhancer to boost your low testosterone.
Ether, methyl, ethyl or
ester moieties are added to the basic compound by some
companies to protect it from liver degradation and extend
its life. These added functional group must be removed by
the liver through enzymatic processes and then eliminated.
The current trend toward the addition of such moieties (also
observed with creatine, arginine, and other compounds)
reduces the active ingredient fraction of the resulting
compound (resulting in a reduced efficiency) and puts an
undue stress upon the liver which has not been studied or
quantified by any company.
In fact,
Testone®
anti estrogen and natural testosterone booster’s
main active compound has been shown to be a more effective
anti-estrogens than tamoxifen (Nolvadex), clomiphen and abc
(Arimidex)[2] because it irreversibly binds to the aromatase
active site, disabling the enzyme to exert its effect on
testosterone, while other competitive inhibitors, like
Arimidex, reversibly bind to the aromatase, providing an
intermittent effect (testosterone can still bind to the
active site of the aromatase enzyme when the binding is
cleaved). This is, in fact, the main reason why this active
compound has been shown to be the only effective therapeutic
agent for the treatment of hormone dependant cancers.
Furthermore, this active
compound is, in
the bodybuilding supplement
Testone®
anti estrogen and natural testosterone booster,
delivered through an advanced and unique delivery system
which increases by 8 fold its availability, makes it more
effective than the original therapeutic formula.
Obviously,
3,6,17-androstenetrione (branded under "6-oxo") and other
anti-aromataze’s activity cannot be compared (significantly
lower) with the one of
Testone®
anti estrogen and natural testosterone booster.
Their much less important anti-aromatase effect (compared
with the
bodybuilding supplement
Testone®
anti estrogen and natural testosterone booster) also
result in a much lower (even negligible) natural
testosterone booster effect. Further more, studies have
shown that the active ingredient, found in popular
anti-estrogen testosterone boosters probably converts to the
estrogens 6-keto-estrone and 6-keto-estradiol (why would
anyone take an anti-estrogen that converts to an estrogen?).
With an
increase of free
free testosterone level over 9000%,
Testone®
anti estrogen and natural testosterone booster is
the currently, by far, the most effective natural
testosterone booster available.
Testone®
anti estrogen and natural testosterone booster can
safely replace or complement testosterone replacement
therapy
Externally administered
testosterone is referred to as exogenous testosterone.
Analogues of testosterone have been prepared, and these show
modified biological activity (e.g., esters of testosterone,
various enols, ethers and also 17-alkyl substituted
testosterone, which exhibit liver toxicity). The absence of
the 19-methyl group, as in 19-nortestosterone reduces
classical androgenic activity but so the extent of protein
anabolism.
Normal total
testosterone level for a healthy male is about 500-600ng/dl.
Too many individuals are in the 200-350ng/dl range due to
environmental estrogens alone. The 1200ng/dl value is
considered as the supra physiological level responsible the
major anabolism occurrence. As a result of all of this
excess testosterone floating around the body, there is a lot
of aromatization to estrogens. The overstimulaiton of
androgen receptors of the hypothalamus results in the loss
of testicular function due to both negative feed-back loops
occurring.
Many bodybuilders know
that by decreasing the amount of circulatory estrogen (this
can be effectively done by using
the bodybuilding supplement
Testone®
anti estrogen and natural testosterone booster),
they are also able to somewhat decrease HPTA
down-regulation.
Testone®
anti estrogen and natural testosterone booster has
shown to rise the total plasmatic testosterone levels above
the 1200ng/dl supra physiological reference level, without
causing the associated estrogen level rise (in fact, it
decreases the estrogen level) responsible for the testicular
shut down.
Bodybuilders (for which
the main goal lies in muscle building) as well as athletes
in quest for strength and power will rapidly observe
prominent results. Increase your low testosterone this
bodybuilding supplement enhancer.
Negative effects of
Testone®
anti estrogen and natural testosterone booster
 Testone®
anti estrogen and natural testosterone booster is
classified as a Natural Health Product. Its formula is
innocuous in that it does not have any known negative effect
when used as per indications. Its active ingredients are
clinically tested organic compounds that have been used for
therapeutic purpose for several years.
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